Antigen Ligation Triggers a Conformational Change within the Constant Domain of the alpha beta T Cell Receptor

Travis Beddoe; Zhenjun Chen; Craig S Clements; Lauren K Ely; Simon R Bushell; Julian P Vivian; Lars Kjer-Nielsen; Siew Siew Pang; Michelle A Dunstone; Yu Chih Liu; Whitney A Macdonald; Matthew A Perugini; Matthew CJ Wilce; Scott R Burrows; Anthony W Purcell; Tony Tiganis; Stephen P Bottomley; James McCluskey; Jamie Rossjohn

Journal article

Antigen Ligation Triggers a Conformational Change within the Constant Domain of the alpha beta T Cell Receptor

Travis Beddoe, Zhenjun Chen, Craig S Clements, Lauren K Ely, Simon R Bushell, Julian P Vivian, Lars Kjer-Nielsen, Siew Siew Pang, Michelle A Dunstone, Yu Chih Liu, Whitney A Macdonald, Matthew A Perugini, Matthew CJ Wilce, Scott R Burrows, Anthony W Purcell, Tony Tiganis, Stephen P Bottomley, James McCluskey, Jamie Rossjohn

Immunity | CELL PRESS | Published : 2009

DOI: 10.1016/j.immuni.2009.03.018

University of Melbourne Researchers

Matt Perugini Author Biochemistry and Molecular Biology

James McCluskey Author

Zhenjun Chen Author Microbiology and Immunology

Grants

Funding Acknowledgements

We thank N. La Gruta and R. Tweten for useful discussions and D. Garboczi for the generous provision of the A6 TCR plasmids. The Australian Research Council (ARC), the National Health and Medical Research Council of Australia (NHMRC), the Roche Organ Transplantation Research Fund, Monash University Strategic grant, and ANZ trustees supported this research. T.B. is an NHMRC CDA fellow; W.A.M. and M.A.D. are supported by NHMRC Peter Doherty Fellowships; L.K.E. is supported by a NHMRC CJ Martin Fellowship; M.C.J.W., S.R. Burrows, and S.P.B. are supported by a NHMRC Senior Research Fellowship; C.S.C. is supported by an ARC QEII fellowship; and J.R. is supported by an ARC Federation Fellowship.