Journal article

Relaxin Family Peptide Receptor-1 Protects against Airway Fibrosis during Homeostasis But Not against Fibrosis Associated with Chronic Allergic Airways Disease

Chrishan S Samuel, Simon G Royce, Bin Chen, Huifang Cao, Jan A Gossen, Geoffrey W Tregear, Mimi LK Tang

Endocrinology | ENDOCRINE SOC | Published : 2009

Abstract

Endogenous relaxin has recently been demonstrated to protect the airway/lung against age-related fibrosis and against inflammation-associated airway fibrosis in animal models of allergic airways disease (AAD). In the current study, we examined the contribution of the primary relaxin receptor, relaxin family peptide receptor-1 (RXFP1), in mediating these effects of relaxin. Lung tissues from healthy aging RXFP1 gene-knockout (Rxfp1(-/-)) and wild-type (Rxfp1(+/+)) mice and from 8- to 10-wk-old Rxfp1(-/-) and Rxfp1(+/+) mice subjected to a mouse model of AAD were assessed for various markers of airway fibrosis and remodeling. Male and female Rxfp1(-/-) mice demonstrated an age-related progress..

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Grants

Funding Acknowledgements

We sincerely thank Ms. Chongxin Zhao for technical assistance.Address all correspondence and requests for reprints to: Assoc. Prof. Mimi Tang, Department of Allergy and Immunology, Royal Children's Hospital or Dr. Chrishan Samuel, University of Melbourne, Parkville 3052, Australia. E-mail: mimi.tang@mcri.edu.au or chrishan.samuel@florey.edu.au.This study was supported by a National Heart Foundation of Australia/National Health and Medical Research Council of Australia (NHMRC) R. D. Wright Fellowship to C. S. S., Salary Support Grants from the Murdoch Children's Research Institute to S. G. R., and M. L. K. T., and a NHMRC Senior Principal Research Fellowship to G. W. T.Disclosure Statement: All authors have nothing to declare.