Pituitary volume and early treatment response in drug-naive first-episode psychosis patients
B Garner, GE Berger, JP Nicolo, A Mackinnon, SJ Wood, CM Pariante, P Dazzan, TM Proffitt, C Markulev, M Kerr, M McConchie, LJ Phillips, C Pantelis, PD McGorry
SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2009
BACKGROUND: An early response to antipsychotic treatment in patients with psychosis has been associated with a better course and outcome. However, factors that predict treatment response are not well understood. The onset of schizophrenia and related disorders has been associated with increased levels of stress and hyper-activation of the hypothalamic-pituitary-adrenal (HPA) axis. This study examined whether pituitary volume at the onset of psychosis may be a potential predictor of early treatment response in first-episode psychosis (FEP) patients. METHODS: We investigated the relationship between baseline pituitary volume and symptomatic treatment response over 12 weeks using mixed model an..View full abstract
Awarded by Medical Research Council
Neumimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory managed by Ms. Bridget Soulsby at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. Or Garner is supported by a NHMRC Postdoctoral Training Fellowship. Assoc. Prof Wood is supported by a NHMRC Career Development Award.