Journal article
Increased D-Lactic Acid Intestinal Bacteria in Patients with Chronic Fatigue Syndrome
John R Sheedy, Richard EH Wettenhall, Denis Scanlon, Paul R Gooley, Donald P Lewis, Neil Mcgregor, David I Stapleton, Henry L Butt, Kenny L De Meirleir
IN VIVO | INT INST ANTICANCER RESEARCH | Published : 2009
Abstract
Patients with chronic fatigue syndrome (CFS) are affected by symptoms of cognitive dysfunction and neurological impairment, the cause of which has yet to be elucidated. However, these symptoms are strikingly similar to those of patients presented with D-lactic acidosis. A significant increase of Gram positive facultative anaerobic faecal microorganisms in 108 CFS patients as compared to 177 control subjects (p<0.01) is presented in this report. The viable count of D-lactic acid producing Enterococcus and Streptococcus spp. in the faecal samples from the CFS group (3.5 x 10(7) cfu/L and 9.8 x 10(7) cfu/L respectively) were significantly higher than those for the control group (5.0 x 10(6) cfu..
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