Journal article

LeishCyc: a biochemical pathways database for Leishmania major

Maria A Doyle, James I MacRae, David P De Souza, Eleanor C Saunders, Malcolm J McConville, Vladimir A Likic

BMC SYSTEMS BIOLOGY | BMC | Published : 2009


BACKGROUND: Leishmania spp. are sandfly transmitted protozoan parasites that cause a spectrum of diseases in more than 12 million people worldwide. Much research is now focusing on how these parasites adapt to the distinct nutrient environments they encounter in the digestive tract of the sandfly vector and the phagolysosome compartment of mammalian macrophages. While data mining and annotation of the genomes of three Leishmania species has provided an initial inventory of predicted metabolic components and associated pathways, resources for integrating this information into metabolic networks and incorporating data from transcript, protein, and metabolite profiling studies is currently lack..

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Awarded by NHMRC

Awarded by Australian Research Council

Funding Acknowledgements

This project was funded by a NH&MRC Program Grant 406601 and the Australian Research Council Discovery grant DP0878227. MJM is an Australian National Health and Medical (NH&MRC) Principal Research Fellow. Authors thank Peter Karp and the BioCyc team for their support and assistance. DPDS, MJM, and VAL thank Metabolomics Australia for providing a stimulating intellectual environment.