Journal article

Age-related Macular Degeneration and Risk of Coronary Heart Disease and Stroke: The Cardiovascular Health Study

Cong Sun, Ronald Klein, Tien Y Wong

OPHTHALMOLOGY | ELSEVIER SCIENCE INC | Published : 2009

Abstract

PURPOSE: To examine the associations of age-related macular degeneration (AMD) with incident coronary heart disease (CHD) and stroke in the Cardiovascular Health Study. DESIGN: Population-based prospective cohort study. PARTICIPANTS: A total of 1786 white and African-American participants free of CHD or 2228 participants free of stroke, aged 69 to 97 years. METHODS: AMD was evaluated from photographs taken in 1997 and 1998. MAIN OUTCOME MEASURES: Incident CHD and stroke ascertained using standardized methods. RESULTS: Of the 1786 persons free of CHD, 303 developed incident CHD over 7 years. Participants with early AMD (n = 277) had a higher cumulative incidence of CHD than participants witho..

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Grants

Awarded by National Heart, Lung, and Blood Institute


Awarded by DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

The research reported in this article was supported by the National Heart, Lung, and Blood Institute (contracts N01-HC-85079 to N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, and U01 HL080295], with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided by the National Heart, Lung, and Blood Institute, National Institute of Health (grant number R21-HL077166) and the Sylvia and Charles Viertel Clinical Investigator Award (TYW). A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm. The sponsor or funding organization had no role in the design or conduct of this research.