Journal article

Plasmodium falciparum-Mediated Induction of Human CD25(hi)Foxp3(hi) CD4 T Cells Is Independent of Direct TCR Stimulation and Requires IL-2, IL-10 and TGF beta

Anja Scholzen, Diana Mittag, Stephen J Rogerson, Brian M Cooke, Magdalena Plebanski

PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2009

Abstract

CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) regulate disease-associated immunity and excessive inflammatory responses, and numbers of CD4(+)CD25(+)Foxp3(+) Tregs are increased during malaria infection. The mechanisms governing their generation, however, remain to be elucidated. In this study we investigated the role of commonly accepted factors for Foxp3 induction, TCR stimulation and cytokines such as IL-2, TGFbeta and IL-10, in the generation of human CD4(+)CD25(+)Foxp3(+) T cells by the malaria parasite Plasmodium falciparum. Using a co-culture system of malaria-infected red blood cells (iRBCs) and peripheral blood mononuclear cells from healthy individuals, we found that two populat..

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University of Melbourne Researchers