Journal article
Plasmodium falciparum-mediated induction of human CD25 hiFoxp3hi CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFβ
A Scholzen, D Mittag, SJ Rogerson, BM Cooke, M Plebanski
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2009
Abstract
CD4+CD25+Foxp3+ regulatory T cells (Tregs) regulate disease-associated immunity and excessive inflammatory responses, and numbers of CD4+CD25+Foxp3+ Tregs are increased during malaria infection. The mechanisms governing their generation, however, remain to be elucidated. In this study we investigated the role of commonly accepted factors for Foxp3 induction, TCR stimulation and cytokines such as IL-2, TGFβL-10, in the generation of human CD4+CD25 +Foxp3+ T cells by the malaria parasite Plasmodium falciparum. Using a co-culture system of malaria-infected red blood cells (iRBCs) and peripheral blood mononuclear cells from healthy individuals, we found that two populations of Foxp3hi and Foxp3i..
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Funding Acknowledgements
This work was supported by the Australian NHMRC (BMC, SJR and MP) and the Howard Hughes Medical Institute International Scholar's Program (support to MP). AS was a recipient of an Endeavour International Postgraduate Research Scholarship and a Melbourne International Research Scholarship at the University of Melbourne, Department of Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.