Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils
Christopher G Adda, Vince J Murphy, Margaret Sunde, Lynne J Waddington, Jesse Schloegel, Gert H Talbo, Kleo Vingas, Vivian Kienzle, Rosella Masciantonio, Geoffrey J Howlett, Anthony N Hodder, Michael Foley, Robin F Anders
Molecular and Biochemical Parasitology | ELSEVIER SCIENCE BV | Published : 2009
Awarded by US National Institutes of Health
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
We thank Professor Ray Norton, and DrsJose Varghese, Malcolm McConville, Danny Hatters and Terry Mulhern for discussions. We also thank Dr Rob Glaisher for help with electron microscopy, Rosemary Condron for N-terminal sequencing, Dr Mustafa Ayhan for carrying out the Q-Star MS analyses, Dr Roberto Cappai for supplying us with AP (1 -42) pepticle and Kaye Wycherley with expert help in producing the anti-MSP2 monoclonal antibodies. This research has been facilitated by access to the Australian Proteome Analysis Facility established under the Australian Government's Major National Research Facilities program. C-terminally hexa-His-tagged 3D7-6H and FC27-6H MSP2 antigens were manufactured by GroPep Pty Ltd. (now Novozymes GroPep Limited) with funding from PATH-MVI. This work was supported by a grant from the US National Institutes of Health (NIH R01AI59229).