Journal article

Cell migration and proliferation during monolayer formation and wound healing

A Tremel, A Cai, N Tirtaatmadja, BD Hughes, GW Stevens, KA Landman, AJ O'Connor

CHEMICAL ENGINEERING SCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2009

Abstract

The interaction of living cells with surfaces is important in applications of biomaterials, such as tissue engineering. Characterising and modelling the attachment, migration and proliferation of cells on materials used for tissue engineering provides valuable insight into their potential applications as well as a means of objective comparison. In this study, proliferation and migration of NIH-3T3 fibroblast cells on tissue culture plastic in vitro were quantified. The development of randomly scattered individual cells into confluent cell monolayers proceeded with cell density following a logistic growth pattern. Travelling cell wavefronts produced in a wound healing assay were modelled with..

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Grants

Awarded by Australian Research Council (ARC)


Funding Acknowledgements

The authors gratefully acknowledge Hai Nguyen for assistance with cell culture, the Australian Research Council (ARC) for funding through Discovery Grants DP0557990 and DP0662804, and the Particulate Fluids Processing Centre, a Special Research Centre of the ARC, for access to infrastructure.