Journal article

Septic shock induces distinct changes in sympathetic nerve activity to the heart and kidney in conscious sheep

Rohit Ramchandra, Li Wan, Sally G Hood, Robert Frithiof, Rinaldo Bellomo, Clive N May

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2009


Sepsis and septic shock are the chief cause of death in intensive care units, with mortality rates between 30 and 70%. In a large animal model of septic shock, we have demonstrated hypotension, increased cardiac output, and tachycardia, together with renal vasodilatation and renal failure. The changes in cardiac sympathetic nerve activity (CSNA) that may contribute to the tachycardia have not been investigated, and the changes in renal SNA (RSNA) that may mediate the changes in renal blood flow and function are unclear. We therefore recorded CSNA and RSNA during septic shock in conscious sheep. Septic shock was induced by administration of Escherichia coli, which caused a delayed hypotension..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by National Heart Foundation Postdoctoral Fellowship

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia (NHMRC) Grant 454615. R. Ramchandra was the recipient of National Heart Foundation Postdoctoral Fellowship PF 07M 3293, and C. N. May was supported by NHMRC Research Fellowships 350328 and 566819. R. Frithiof was the recipient of a postdoctoral fellowship from the Swedish Heart-Lung Foundation.