Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis
Renwick CJ Dobson, Matthew A Perugini, Geoffrey B Jameson, Juliet A Gerrard
Biochimie | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2009
Awarded by Royal Society of New Zealand
The authors acknowledge Mike Griffin (University of Melbourne, Australia), Antonia Miller (University of Monash, Australia), and especially Emma McMurtrie (ITX Ltd, Australia) for critical discussion. We thank Jackie Healy for impervious, yet unruffled, technical support, and Sean Devenish for (S)-ASA and inspiration. This work was funded by the Royal Society of New Zealand Marsden Fund [contract UOC303]. Funding for the protein X-ray diffraction facility was provided, in part, by The Allan Wilson Centre for Molecular Ecology and Evolution. R.C.J.D acknowledges the University of Melbourne C.R. Roper Research Fellowship for financial support.