Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers
Kristyn A Bates, Hamid R Sohrabi, Mark Rodrigues, John Beilby, Satvinder S Dhaliwal, Kevin Taddei, Arthur Criddle, Megan Wraith, Matthew Howard, Georgia Martins, Athena Paton, Pankaj Mehta, Jonathan K Foster, Ian J Martins, Nicola T Lautenschlager, Frank L Mastaglia, Simon M Laws, Samuel E Gandy, Ralph N Martins
JOURNAL OF ALZHEIMERS DISEASE | IOS PRESS | Published : 2009
A strong link is indicated between cardiovascular disease (CVD) and risk for developing Alzheimer's disease (AD), which may be exacerbated by the major AD genetic risk factor apolipoprotein Eepsilon4 (APOEepsilon4). Since subjective memory complaint (SMC) may potentially be an early indicator for cognitive decline, we examined CVD risk factors in a cohort of SMC. As amyloid-beta (Abeta) is considered to play a central role in AD, we hypothesized that the CVD risk profile (increased LDL, reduced HDL, and increased body fat) would be associated with plasma Abeta levels. We explored this in 198 individuals with and without SMC (average age = 63 years). Correlations between Abeta40 and HDL were ..View full abstract
Awarded by National Institute of Health
Awarded by NATIONAL INSTITUTE ON AGING
Funding for this project was provided by the NH&MRC, the National Institute of Health (Grant#7P01AG010491-12), The McCusker Foundation for Alzheimer's Disease Research, and the Western Australian State Government through the Center of Excellence for Alzheimer's Disease Research and Care. The authors thank Professor David Bruce for his critical review of this manuscript.