Serial increased cardiac troponin T predicts mortality in asymptomatic patients treated with chronic haemodialysis

Abstract

Background: A single detectable cardiac troponin predicts mortality in patients treated with dialysis. There are limited data on changes in troponin concentration over time and the clinical implications of serial troponin measurement. Methods: Serial cardiac troponin T (cTnT) was assayed five times over 12 months in a prospective cohort study of patients with end-stage kidney disease treated with haemodialysis. A concentration of cTnT ≥0.04 μg/L was considered increased. Mortality and cardiovascular events were analysed by survival analysis, according to the serial troponin results. Results: From 100 patients who provided a baseline sample for cTnT, 81 completed five serial measurements. The..