Chronic type 1 diabetes in spontaneously hypertensive rats leads to exacerbated cardiac fibrosis
Mary Jane Black, Angelo D'Amore, Alana Auden, Laura Stamp, Tanya Osicka, Sianna Panagiotopoulos, George Jerums
CARDIOVASCULAR PATHOLOGY | ELSEVIER SCIENCE INC | Published : 2010
INTRODUCTION: Diabetes in human subjects is often associated with hypertension. The aim of this study was to examine the development of cardiac fibrosis following induction of type 1 diabetes in genetically hypertensive rats. METHODS: Diabetes was induced by streptozotocin (STZ) injection in 8-week-old normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs) for a duration of 16 or 24 weeks. Aged-matched, nondiabetic WKY and SHRs were used as controls. At termination of treatment, the rats were anaesthetized, hearts arrested in diastole and perfusion fixed. A comprehensive examination of cardiac fibrosis throughout the right and left ventricles was undertaken in picros..View full abstract
This study was supported by the National Health and Medical Research Council of Australia and the Juvenile Diabetes Research Foundation of Australia.