Journal article

Chronic type 1 diabetes in spontaneously hypertensive rats leads to exacerbated cardiac fibrosis

Mary Jane Black, Angelo D'Amore, Alana Auden, Laura Stamp, Tanya Osicka, Sianna Panagiotopoulos, George Jerums

CARDIOVASCULAR PATHOLOGY | ELSEVIER SCIENCE INC | Published : 2010

Abstract

INTRODUCTION: Diabetes in human subjects is often associated with hypertension. The aim of this study was to examine the development of cardiac fibrosis following induction of type 1 diabetes in genetically hypertensive rats. METHODS: Diabetes was induced by streptozotocin (STZ) injection in 8-week-old normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs) for a duration of 16 or 24 weeks. Aged-matched, nondiabetic WKY and SHRs were used as controls. At termination of treatment, the rats were anaesthetized, hearts arrested in diastole and perfusion fixed. A comprehensive examination of cardiac fibrosis throughout the right and left ventricles was undertaken in picros..

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