gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

Julia Bollrath; Toby J Phesse; Vivian A von Burstin; Tracy Putoczki; Moritz Bennecke; Trudie Bateman; Tim Nebelsiek; Therese Lundgren-May; Oezge Canli; Sarah Schwitalla; Vance Matthews; Roland M Schmid; Thomas Kirchner; Melek C Arkan; Matthias Ernst; Florian R Greten

Journal article

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

Julia Bollrath, Toby J Phesse, Vivian A von Burstin, Tracy Putoczki, Moritz Bennecke, Trudie Bateman, Tim Nebelsiek, Therese Lundgren-May, Oezge Canli, Sarah Schwitalla, Vance Matthews, Roland M Schmid, Thomas Kirchner, Melek C Arkan, Matthias Ernst, Florian R Greten

Cancer Cell | CELL PRESS | Published : 2009

DOI: 10.1016/j.ccr.2009.01.002

University of Melbourne Researchers

Tracy Putoczki Author Surgery - Royal Melbourne Hospital

Toby Phesse Author Infectious Diseases

Matthias Ernst Author Surgery - Royal Melbourne Hospital

Grants

Awarded by Wilhelm Sander-Stiftung

Awarded by Deutsche Krebshilfe

Awarded by Deutsche Forschungsgemeinschaft

Awarded by Fritz Thyssen Stiftung

Funding Acknowledgements

We thank B. Wittig, K. Retzlaff, and V. Feakes for excellent technical assistance. We also thank D. Gumucio for providing villin-Cre mice and W. Reindl for providing Stat3<SUP>lox/lox</SUP> mice with the permission of K. Takeda. M.C.A. was supported by grants obtained from the Wilhelm Sander-Stiftung (2005.146.1) and Deutsche Krebshilfe (107977). M.E. was supported by the National Health and Medical Research Council of Australia (NHMRC) and by an NHMRC Senior Research Fellowship. F.R.G. was supported by the Deutsche Forschungsgemeinschaft (Emmy Noether Programme Gr1916/2-2, SFB 456), Deutsche Krebshilfe (106772), and Fritz Thyssen Stiftung (10.05.2.168).