Journal article

Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling

D Ciznadija, R Tothill, ML Waterman, L Zhao, D Huynh, RM Yu, M Ernst, S Ishii, T Mantamadiotis, TJ Gonda, RG Ramsay, J Malaterre

CELL DEATH AND DIFFERENTIATION | NATURE PUBLISHING GROUP | Published : 2009

Abstract

Aberrant Wnt signaling mediated by mutations affecting APC (adenomatous polyposis coli) or beta-catenin initiates the majority of human colorectal cancers (CRC) and drives tumorigenesis through the activation of specific genes such as MYC. We report here a novel association whereby another oncogenic transcription factor, MYB/c-Myb, is necessary for intestinal adenoma development directed by activated Wnt signaling. APC(Min/+) mice in which c-myb is haploinsufficient survive longer than wild-type APC(Min/+) animals due to a delay in adenoma formation. Intestinal adenomas from APC(Min/+) mice were assessed and found to have high levels of c-myc gene expression. We explored the relationship bet..

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