Journal article
Intervention in individuals at ultra-high risk for psychosis: A review and future directions
PD McGorry, B Nelson, GP Amminger, A Bechdolf, SM Francey, G Berger, A Riecher-Rössler, J Klosterkötter, S Ruhrmann, F Schultze-Lutter, M Nordentoft, I Hickie, P McGuire, M Berk, EYH Chen, MS Keshavan, AR Yung
Journal of Clinical Psychiatry | Published : 2009
DOI: 10.4088/JCP.08r04472
Abstract
Objective: Over the last 15 years, a focus on early intervention in psychotic disorders has emerged. Initially, the early psychosis movement focused on timely recognition and phase-specific treatment of first-episode psychosis. However, early psychosis researchers suspected that pushing the point of intervention even further back to the prodromal phase of psychotic disorders may result in even better outcomes. This article reviews intervention research in the ultra-high-risk phase of psychotic disorders. Data sources: A literature search of intervention trials with ultra-high-risk cohorts published after 1980 was conducted on PubMed with the search terms prodrome and intervention. Study sele..
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Funding Acknowledgements
Financial disclosure: Dr McGorry has been a consultant to and has received honoraria from Pfizer, AstraZeneca, Janssen, and Eli Lilly; has received grant/research support from AstraZeneca; and has served on speakers or advisory boards of Pfizer. Dr Bechdolf has served on speakers or advisory boards of Eli Lilly, Sanofi-Aventis, and Janssen-Cilag. Dr Berk has been a consultant to AstraZeneca, Eli Lilly, and Janssen-Cilag; has received grant/research support from the National Health and Medical Resource Council, Stanley Medical Research Institute, and Eli Lilly; has received honoraria from AstraZeneca, Servier, Eli Lilly, and Janssen-Cilag; and has served on speakers or advisory boards of AstraZeneca, Eli Lilly, Lundbeck, Pfizer, and Wyeth. Drs Nelson, Amminger, Francey, Berger, Riecher-Rossler, Klosterkiitter, Ruhrmann, SchultzeLutter, Nordentoft, Hickie, McGuire, Chen, Keshavan, and Yung report no financial or other relationship relevant to the subject of the article.