Journal article

Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?

Amelia S Koe, Nigel C Jones, Michael R Salzberg

FRONTIERS IN BEHAVIORAL NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2009

Abstract

The pathogenesis of mesial temporal lobe epilepsy (MTLE), the most prevalent form of refractory focal epilepsy in adults, is thought to begin in early life, even though seizures may not commence until adolescence or adulthood. Amongst the range of early life factors implicated in MTLE causation (febrile seizures, traumatic brain injury, etc.), stress may be one important contributor. Early life stress is an a priori agent deserving study because of the large amount of neuroscientific data showing enduring effects on structure and function in hippocampus and amygdala, the key structures involved in MTLE. An emerging body of evidence directly tests hypotheses concerning early life stress and l..

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