Journal article

Effects of Lactobacillus GG treatment during pregnancy on the development of fetal antigen-specific immune responses

RJ Boyle, L-J Mah, A Chen, S Kivivuori, RM Robins-Browne, ML-K Tang



BACKGROUND: Several clinical trials suggest that probiotics may have a role in the prevention of eczema. The optimal timing and mechanisms underlying this intervention are not clear. In particular it is not known whether such treatment works during pregnancy or whether postnatal exposure is important. OBJECTIVE: We investigated whether the probiotic Lactobacillus rhamnosus strain GG (LGG) influences fetal immune responses when administered to pregnant women, as a possible mechanism for its protective effects against the development of eczema. METHODS: Peripheral blood mononuclear cell from 11 adults treated with LGG, and cord blood mononuclear cells (CBMCs) from 73 women participating in a r..

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Awarded by Medical Research Council

Funding Acknowledgements

We are grateful to the participants for volunteering for these studies. The studies were funded by grants from the Jack Brockhoff Foundation, the Murdoch Children's Research Institute and the Ilhan Food Allergy Foundation. Mimi Tang was supported by a Murdoch Children's Research Institute Salary Grant. Robert Boyle was supported by a University of Melbourne Baillieu Scholarship and a Murdoch Children's Research Institute Postgraduate Scholarship. LGG and placebo capsules were manufactured and supplied by Dicofarm Ltd ( Roma, Italy). We are grateful to Dr Susan Donath of the Murdoch Children's Research Institute Clinical Epidemiology and Biostatistics Units for advice regarding statistical analyses, to Professors Patrick Holt and Susan Prescott for advice regarding laboratory methodology, to Professors Roy RobinsBrowne and Seppo Salminen for advice regarding study design and to Matt Burton, Noel Cranswick, Kay Hynes, Christine Plover, Michael Permezel, Val Bryant, Christine Axelrad, Sally Moore, Sampo Lahtinen and Amy Bin Chen for their assistance in the conduct of these studies.