Journal article

The reducible complexity of a mitochondrial molecular machine

Abigail Clements, Dejan Bursac, Xenia Gatsos, Andrew J Perry, Srgjan Civciristov, Nermin Celik, Vladimir A Likic, Sebastian Poggio, Christine Jacobs-Wagner, Richard A Strugnell, Trevor Lithgow

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2009

Abstract

Molecular machines drive essential biological processes, with the component parts of these machines each contributing a partial function or structural element. Mitochondria are organelles of eukaryotic cells, and depend for their biogenesis on a set of molecular machines for protein transport. How these molecular machines evolved is a fundamental question. Mitochondria were derived from an alpha-proteobacterial endosymbiont, and we identified in alpha-proteobacteria the component parts of a mitochondrial protein transport machine. In bacteria, the components are found in the inner membrane, topologically equivalent to the mitochondrial proteins. Although the bacterial proteins function in si..

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University of Melbourne Researchers