Journal article

Retinal Vascular Fractal Dimension and Risk of Early Diabetic Retinopathy A prospective study of children and adolescents with type 1 diabetes

Shueh Wen Lim, Gerald Liew, Ning Cheung, FM Amirul Islam, Jie J Wang, Alicia J Jenkins, Kim C Donaghue, Tien Y Wong



OBJECTIVE: To examine the prospective association of retinal vascular fractal dimension with diabetic retinopathy risk in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS: This was a hospital-based prospective study of 590 patients aged 12-20 years with type 1 diabetes free of retinopathy at baseline. All patients had seven-field retinal photographs taken of both eyes. Incident retinopathy was ascertained from retinal photographs taken at follow-up visits. Fractal dimension was measured from baseline photographs using a computer-based program following a standardized protocol. RESULTS: Over a mean +/- SD follow-up period of 2.9 +/- 2.0 years, 262 participants developed mild non..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study is supported by the National Health and Medical Research Council Grant 475605 (to T.Y.W., K. C. D., and A.J.J.), the Juvenile Diabetes Research Foundation Innovative Grant (to T.Y.W., K.C.D., A.J.J., and N.C.), and the Royal Victorian Eye and Ear Hospital Research Grant (to N.C.).