Journal article

Occurrence, Plasticity, and Evolution of the vpma Gene Family, a Genetic System Devoted to High-Frequency Surface Variation in Mycoplasma agalactiae

Laurent-Xavier Nouvel, Marc Marenda, Pascal Sirand-Pugnet, Eveline Sagne, Michelle Glew, Sophie Mangenot, Valerie Barbe, Aurelien Barre, Stephane Claverol, Christine Citti

JOURNAL OF BACTERIOLOGY | AMER SOC MICROBIOLOGY | Published : 2009

Abstract

Mycoplasma agalactiae, an important pathogen of small ruminants, exhibits a very versatile surface architecture by switching multiple, related lipoproteins (Vpmas) on and off. In the type strain, PG2, Vpma phase variation is generated by a cluster of six vpma genes that undergo frequent DNA rearrangements via site-specific recombination. To further comprehend the degree of diversity that can be generated at the M. agalactiae surface, the vpma gene repertoire of a field strain, 5632, was analyzed and shown to contain an extended repertoire of 23 vpma genes distributed between two loci located 250 kbp apart. Loci I and II include 16 and 7 vpma genes, respectively, with all vpma genes of locus ..

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