Induction of spermatogenesis and fertility during gonadotropin treatment of Gonadotropin-Deficient infertile men: Predictors of fertility outcome

Abstract

Background: The induction of spermatogenesis and fertility with gonadotropin therapy in gona-dotropin-def icient men varies in rate and extent. Understanding the predictors of response would inform clinical practice but requires multivariate analyses in sufficiently large clinical cohorts that are suitably detailed and frequently assessed.Design, Setting, and Participants: A total of 75 men, with 72 desiring fertility, was treated at two academic andrology centers for a total of 116 courses of therapy from 1981-2008.Outcomes: Semen analysis and testicular examination were performed every 3 months.Results: A total of 38 men became fathers, including five through assisted reproduction. The med..