Depression and Bone Metabolism A Review
Lana J Williams, Julie A Pasco, Felice N Jacka, Margaret J Henry, Seetal Dodd, Michael Berk
PSYCHOTHERAPY AND PSYCHOSOMATICS | KARGER | Published : 2009
BACKGROUND: There are data to suggest low bone mineral density is disproportionately prevalent among those with psychiatric disorders. This paper aims to review the current evidence on the relationship between depression and bone mineral density, and identify potential mechanisms. METHODS: Relevant sources were identified from the Pubmed and Web of Science (ISI) databases from the first relevant publication in 1994 to the present, 2007, using a combination of key words and terms including depression, major depressive disorder, osteoporosis, bone mineral density, hypothalamic-pituitary-adrenal axis, cortisol, cytokines, leptin, antidepressants, selective serotonin reuptake inhibitors, smoking..View full abstract
The study was supported by the National Health and Medical Research Council of Australia and an unrestricted educational grant from Eli Lilly. Postgraduate scholarships were provided by the University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences, and the Australian Rotary Health Research Fund.