Journal article

Depression and Bone Metabolism A Review

Lana J Williams, Julie A Pasco, Felice N Jacka, Margaret J Henry, Seetal Dodd, Michael Berk

PSYCHOTHERAPY AND PSYCHOSOMATICS | KARGER | Published : 2009

Abstract

BACKGROUND: There are data to suggest low bone mineral density is disproportionately prevalent among those with psychiatric disorders. This paper aims to review the current evidence on the relationship between depression and bone mineral density, and identify potential mechanisms. METHODS: Relevant sources were identified from the Pubmed and Web of Science (ISI) databases from the first relevant publication in 1994 to the present, 2007, using a combination of key words and terms including depression, major depressive disorder, osteoporosis, bone mineral density, hypothalamic-pituitary-adrenal axis, cortisol, cytokines, leptin, antidepressants, selective serotonin reuptake inhibitors, smoking..

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