Journal article

Saccadic trajectory in Huntington's disease

Joanne Fielding, Nellie Georgiou-Karistianis, Lynette Millist, Michael Fahey, Owen White

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY | CAMBRIDGE UNIV PRESS | Published : 2006

Abstract

Trajectories of saccadic eye movements can be modulated by the presence of a competing visual distractor. It is proposed that the superior colliculus (SC) controls the initial deviation through competitive lateral interactions. Given the ramifications of connections between basal ganglia (BG) thalamo-cortical circuitry and the SC, it was anticipated that this modulation would be differentially effected in those with Huntington's disease, which in its early stages is primarily a disorder of the BG. Horizontal deviation was determined for exogenously driven and endogenously driven vertical saccades in the presence of peripheral distractors. For neurologically healthy participants, the initial ..

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