Biomechanisms for modelling cerebral cortical folding

Abstract

Understanding the biomechanical mechanisms by which the cerebral cortex folds is a fundamental problem in neuroscience. Current mathematical models of cortical folding do not include three dimensional geometry or measurement of cortical growth in developing brains extracted from experimental data. We present two biomechanical models of cortical folding which integrate 3D geometry and information taken from MRI scans of fetal sheep brains at a number of key developmental stages. The first model utilises diffusion tensor imaging (DTI) measurements of white matter fibre orientation in the fetal sheep brains as a cue to the tension forces that may regulate folding. In the second model, tangentia..