Chronic Exposure to High Levels of Zinc or Copper has Little Effect on Brain Metal Homeostasis or A beta Accumulation in Transgenic APP-C100 Mice
Christa J Maynard, Roberto Cappai, Irene Volitakis, Katrina M Laughton, Colin L Masters, Ashley I Bush, Qiao-Xin Li
CELLULAR AND MOLECULAR NEUROBIOLOGY | SPRINGER/PLENUM PUBLISHERS | Published : 2009
Aberrant metal homeostasis may enhance the formation of reactive oxygen species and Abeta oligomerization and may therefore be a contributing factor in Alzheimer's disease. This study investigated the effect of chronic high intake of dietary Zn or Cu on brain metal levels and the accumulation and solubility of Abeta in vivo, using a transgenic mouse model that over expresses the C-terminal containing Abeta fragment of human amyloid precursor protein but does not develop amyloid deposits. Exposure to chronic high Zn or Cu in the drinking water resulted in only slight elevations of the respective metals in the brain. Total Abeta levels were unchanged although soluble Abeta levels were slightly..View full abstract
We thank Ms. Tina Cardamone for assisting with immunohistochemistry. This work was supported in part by grants from the National Health and Medical Research Council of Australia.