Journal article

Bacille Calmette-Guerin vaccine-related disease in HIV-infected children: a systematic review

P Azzopardi, CM Bennett, SM Graham, T Duke

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | Published : 2009

Abstract

OBJECTIVE: To describe the characteristics and risk of bacille Calmette-Guérin (BCG) vaccine related disease in human immunodeficiency virus (HIV) infected infants. METHODS: Systematic literature review of articles published from 1950 to April 2009 in the English language. We identified all microbiologically confirmed cases of disseminated BCG disease in vertically HIV-infected children reported in the literature. RESULTS: Sixteen observational studies and 11 case reports/series were included. Observational studies suffered from high rates of loss to follow-up and death. Loco-regional BCG disease was reported in both HIV-infected and non-infected children. Disseminated BCG disease was report..

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