Journal article
The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia
JP Van Geertruyden, E Van Eijk, F Yosaatmadja, W Kasongo, M Mulenga, U D'Alessandro, S Rogerson
Malaria Journal | Published : 2009
Abstract
Background. HIV-1 infection affects malaria humeral immunity during pregnancy, but data for non-pregnant adults are lacking. This study reports the impact of HIV-1 infection and other variables on the level of malaria humeral immunity in adults with clinical malaria and whether humeral immune suppression was a risk factor for treatment failure. Methods. Sera of 224 HIV-1 infected and 115 uninfected adults were compared for IgG to merozoite antigens AMA-1 and MSP2 (3D7 and FC27 types) determined by ELISA, and for IgG to the Variant Surface Antigens (VSA) of three different parasite line E8B, A4 and HCD6 determined by flow cytometry. Results. Compared to HIV-1 uninfected adults, AMA-1 IgG was ..
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Funding Acknowledgements
Funding was received by the Belgian Development Co-operation in the framework of an institutional collaboration between the TDRC in Ndola and the ITM in Antwerp, and from the National Health and Medical Research Council of Australia. We would like to thank all the patients and their families who contributed to this study. Sincere thanks also to the staff of the health centers where the study was carried out. We are also grateful to the Director TDRC for his support and to the Director DHMT for offering his clinic facilities to the study.