Journal article

Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia

Luca Cocchi, Mark Walterfang, Renee Testa, Stephen J Wood, Marc L Seal, John Suckling, Tsutomu Takahashi, Tina-Marie Proffitt, Warrick J Brewer, Christopher Adamson, Bridget Soulsby, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis



Spatial working memory (SWM) dysfunction has been suggested as a trait marker of schizophrenia and implicates a diffuse network involving prefrontal, temporal and parietal cortices. However, structural abnormalities in both grey and white matter in relation to SWM deficits are largely unexplored. The current magnetic resonance imaging (MRI) study examined this relationship in a sample of young first-episode schizophrenia (FES) patients using a whole-brain voxel-based method. SWM ability of 21 FES patients and 41 comparable controls was assessed by the CANTAB SWM task. Using an automated morphometric analysis of brain MRI scans, we assessed the relationship between SWM abilities and both grey..

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Awarded by Swiss National Foundation

Awarded by NHMRC

Funding Acknowledgements

The Swiss National Foundation for the Scientific Research supported this study (LC) PBLAB-119622 and PBLAB3-119622; SJW was supported by a NHMRC Clinical Career Development Award (359223) (SJW 578) and MW was supported by a Pfizer NSR grant and by Melbourne Health. This study was also supported by NHMRC Program Grants (566529 579 and 350241) and NHMRC Project Grants (145627, 145737, 981112. 970598, and 970599).