Journal article

Family-based genetic association study of insulin-like growth factor I microsatellite markers and premenopausal breast cancer risk

Gordon Fehringer, Norman F Boyd, Julia A Knight, Andrew D Paterson, Gillian S Dite, Graham G Giles, Melissa C Southey, Irene L Andrulis, John L Hopper, Hilmi Ozcelik

Breast Cancer Research and Treatment | SPRINGER | Published : 2009


Several studies suggest that higher circulating insulin-like growth factor I (IGF-I) levels are associated with premenopausal breast cancer risk. Breast cancer risk and circulating IGF-I concentration appear to be partly heritable, thus genetic variation at IGF1 could influence IGF-I levels and breast cancer risk. We investigated the association of IGF1 CA repeat variants with premenopausal breast cancer risk using a family-based design. The study sample included 840 families from the Ontario Familial Breast Cancer Registry (OFBCR) and the Australian Breast Cancer Family Registry (ABCFR). Three CA repeat variants, at 5', 3', and in intron 2 were genotyped (5'CA, 3'CA, In2CA). We found severa..

View full abstract


Awarded by National Cancer Institute, National Institutes of Health


Funding Acknowledgements

We thank Hamdi Jarjanazi and Keith Wong for their contributions to this study. This work was supported by the National Cancer Institute, National Institutes of Health under RFA-CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry and P.I.s [including P.I.s from Cancer Care Ontario (U01 CA69467) and University of Melbourne (U01 CA69638)]. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the CFR, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the CFR.