Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide
W Mei Kok, Denis B Scanlon, John A Karas, Luke A Miles, Deborah J Tew, Michael W Parker, Kevin J Barnham, Craig A Hutton
CHEMICAL COMMUNICATIONS | ROYAL SOC CHEMISTRY | Published : 2009
Covalently cross-linked homodimeric Abeta peptides have been prepared by solid-phase peptide synthesis by exploiting 'site-site interactions', and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.
This work was supported by the National Health and Medical Research Council (SRF to KJB) and the Australian Research Council (Federation Fellowship to MWP). Access to equipment and technical assistance through the Bio21 Collaborative Crystallisation Centre and the Bio21 Institute Electron Microscopy and Research Transfer Facilities is gratefully acknowledged.