Journal article

Progressive Brain Changes on Serial Manganese-Enhanced MRI following Traumatic Brain Injury in the Rat

Viviane Bouilleret, Lisa Cardamone, Ying Rui Liu, Ke Fang, Damian E Myers, Terence J O'Brien

JOURNAL OF NEUROTRAUMA | MARY ANN LIEBERT, INC | Published : 2009

Abstract

Traumatic brain injury (TBI) has a high incidence of long-term morbidity. Manganese-enhanced MRI (MEMRI) provides high contrast structural and functional detail of the brain in-vivo. The study utilized serial MEMRI scanning in the fluid percussion injury (FPI) rat's model to assess long-term changes in the brain following TBI. Rats underwent a left-sided craniotomy and a 3.5 atmosphere FPI pulse (n = 23) or sham procedure (n = 22). MEMRI acquisition was performed at baseline, 1 day, 1 month, and 6 months after FPI. Volume changes and MnCl(2) enhancement were measured blindly using region-of-interest analysis and the results analyzed with repeated measures MANOVA. Compared to the shams, FPI a..

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