Progressive Brain Changes on Serial Manganese-Enhanced MRI following Traumatic Brain Injury in the Rat
Viviane Bouilleret, Lisa Cardamone, Ying Rui Liu, Ke Fang, Damian E Myers, Terence J O'Brien
JOURNAL OF NEUROTRAUMA | MARY ANN LIEBERT, INC | Published : 2009
Traumatic brain injury (TBI) has a high incidence of long-term morbidity. Manganese-enhanced MRI (MEMRI) provides high contrast structural and functional detail of the brain in-vivo. The study utilized serial MEMRI scanning in the fluid percussion injury (FPI) rat's model to assess long-term changes in the brain following TBI. Rats underwent a left-sided craniotomy and a 3.5 atmosphere FPI pulse (n = 23) or sham procedure (n = 22). MEMRI acquisition was performed at baseline, 1 day, 1 month, and 6 months after FPI. Volume changes and MnCl(2) enhancement were measured blindly using region-of-interest analysis and the results analyzed with repeated measures MANOVA. Compared to the shams, FPI a..View full abstract
Awarded by Victorian Government Transport Accident Commission (TAC)
Funding for this project was provided by the Victorian Government Transport Accident Commission (TAC) in the form of a Victorian Neurotrauma Initiative Project grant (DP0023).