Correlation of Light-Flicker-Induced Retinal Vasodilation and Retinal Vascular Caliber Measurements in Diabetes
Thanh T Nguyen, Ryo Kawasaki, Andreas J Kreis, Jie Jin Wang, Jonathan Shaw, Walthard Vilser, Tien Y Wong
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2009
PURPOSE: Subtle changes in retinal vascular caliber have been shown to predict diabetic retinopathy and other diabetic complications. This study was undertaken to investigate whether retinal vascular caliber correlates with light-flicker-induced retinal vasodilation, a measure of endothelial function. METHODS: The participants were 224 persons with diabetes (85 type 1 and 139 type 2) and 103 persons without diabetes (controls). Flicker-induced retinal vasodilation (percentage increase over baseline diameter) was measured with a vessel analyzer. Retinal vascular caliber was measured from digital retinal photographs according to a standardized, validated protocol. Data from both right and left..View full abstract
Supported by a grant from the Diabetes Australia Research Trust (TTN, JJW, TYW).