Journal article
Metronidazole resistance in Trichomonas vaginalis from highland women in Papua New Guinea
JA Upcroft, LA Dunn, T Wal, S Tabrizi, MG Delgadillo-Correa, PJ Johnson, S Garland, P Siba, P Upcroft
Sexual Health | CSIRO PUBLISHING | Published : 2009
DOI: 10.1071/SH09011
Abstract
Background: The prevalence of the sexually transmissible protozoan parasite Trichomonas vaginalis in the highlands of Papua New Guinea (PNG) has been reported to be as high as 46% and although not previously studied in Papua New Guinea, clinical resistance against metronidazole (Mz), the drug most commonly used to treat trichomoniasis, is well documented worldwide. This study was primarily aimed at assessing resistance to Mz in T. vaginalis strains from the Goroka region. Methods: Consenting patients presenting at the Goroka Base Hospital Sexually Transmitted Diseases (STD) Clinic and local women were asked to provide two vaginal swabs: one for culturing of the parasite; and one for polymera..
View full abstractGrants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
We thank all those involved in the collection of isolates used in this study especially Hannah Nivea of the PNGIMR, and all those from the Goroka Base Hospital. We acknowledge Lynette Corbeil of University of California, San Diego for kindly allowing us to use T. vaginalis isolates from her collection in this study. This work was made possible through the contribution and enthusiasm of the PNGIMR. It was supported by a Winston Churchill Memorial Trust Travel Fellowship to J.A.U. and by the Australian Centre for International and Tropical Health and Nutrition. The work carried out in this study was approved by the Medical Research Advisory Committee of Papua New Guinea. We acknowledge support by an NIH U01 Cooperative Research Agreement AI75527.