Journal article

Five Polymorphisms and Breast Cancer Risk: Results from the Breast Cancer Association Consortium

Mia M Gaudet, Roger L Milne, Angela Cox, Nicola J Camp, Ellen L Goode, Manjeet K Humphreys, Alison M Dunning, Jonathan Morrison, Graham G Giles, Gianluca Severi, Laura Baglietto, Dallas R English, Fergus J Couch, Janet E Olson, Xianshu Wang, Jenny Chang-Claude, Dieter Flesch-Janys, Sascha Abbas, Ramona Salazar, Arto Mannermaa Show all



Previous studies have suggested that minor alleles for ERCC4 rs744154, TNF rs361525, CASP10 rs13010627, PGR rs1042838, and BID rs8190315 may influence breast cancer risk, but the evidence is inconclusive due to their small sample size. These polymorphisms were genotyped in more than 30,000 breast cancer cases and 30,000 controls, primarily of European descent, from 30 studies in the Breast Cancer Association Consortium. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) as a measure of association. We found that the minor alleles for these polymorphisms were not related to invasive breast cancer risk overall in women of European descent: ECCR4 per-allele OR (95% CI) = 0.99 ..

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Awarded by Australian National Health and Medical Research Council

Awarded by National Institutes of Health

Awarded by U.S. medical research and materiel command breast cancer IDEA award

Awarded by Deutsche Krebshilfe e.V.

Awarded by The Academy of Finland

Awarded by Deutsche Krebshilfe

Awarded by Federal Ministry of Education and Research (BMBF) Germany

Awarded by Dutch Cancer Society

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by National Cancer Institute (USA)

Awarded by National Cancer Institute (NCI)

Awarded by NCT

Awarded by National Research and Development Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea

Awarded by Lon v smith Foundation (LVSF)

Awarded by Susan G. Komen Foundation

Awarded by Utah Cancer Registry

Awarded by U.S. Army Medical Research and Materiel Command

Awarded by Cancer Research UK


Funding Acknowledgements

The authors are grateful to Study Coordinators, Laboratory Specialst Kim Nguyen, and Computer Specialist Jathine Wong. We wish to thank Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study (funded by NHMRC grants 145684, 288704 and 454508) for their contributions to this resource, and the many families who contribute to kConFab. kConFab is supported by grants from the National Breast Cancer Foundation, the National Health and Medical Research Council (NHMRC) and by the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. ACS/AOCS: The AOCS Management Group (D Bowtell, G Chenevix-Trench, A deFazio, D Gertig, A Green, P Webb) gratefully acknowledges the contribution of all the clinical and scientific collaborators (see, AOCS and the ACS Management Group (A Green, P Parsons, N Hayward, P Webb, D Whiteman) thank all of the project staff, collaborating institutions and Study participants. Financial support was provided by: U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, the Cancer Council Tasmania and Cancer Foundation of Western Australia (AOCS study); The National Health and Medical Research Council of Australia (199600) (ACS study). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the CFRs, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government or the CFRs Centers. The genotyping and analysis were supported by grants from the National Health and Medical Research Council (NHMRC). ABS was funded by an NHMRC Career Development Award, and GC-T and JLH are NHMRC Senior Principal Research Fellows.