Journal article

Corpus callosum size and shape in individuals with current and past depression

Mark Walterfang, Murat Yuecel, Sarah Barton, David C Reutens, Amanda G Wood, Jian Chen, Valentina Lorenzetti, Dennis Velakoulis, Christos Pantelis, Nicholas B Allen



BACKGROUND: The corpus callosum enables the efficient linking of the two cerebral hemispheres. Reductions in the size of the anterior callosum have been described in geriatric depression, although findings in young adults have been much more equivocal. METHODS: Data was acquired in 26 currently depressed (mean age 32.15 years, 5/26 male) and 28 remitted non-geriatric adults (mean age 36.36 years, 7/28 male), and 32 control subjects (mean age 34.41 years, 11/32 male). The total area, length and curvature of the callosum, and regional thickness along 39 points, from a mid-sagittal T1-weighted magnetic resonance image were compared across the groups. RESULTS: Total area, length and curvature di..

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Awarded by Australian Research Council

Awarded by NHMRC Clinical Research Training

Awarded by NHMRC Clinical Career Development

Funding Acknowledgements

This research was supported by a grant from the Australian Research Council (ID DP0557663). Dr. Walterfang was supported by a Pfizer Neuroscience Research Grant and a Stanley Research Centre Grant. Dr. Wood was supported by an NHMRC Clinical Research Training Fellowship (251755). Dr. Yucel is Supported by a NHMRC Clinical Career Development Award (I.D. 509345). Ms. Lorenzetti is supported by the Endeavour International Postgraduate Research Scholarship (IPRS) and the Melbourne International Research Scholarship (MIRS). Dr. Allen is supported by the Colonial Foundation. Neuroimaging analysis was facilitated by the Neuropsychiatry; Imaging Laboratory managed by Ms. Bridget Soulsby at the Melbourne; Neuropsychiatry Centre and supported by Neurosciences Victoria. The authors thank Dr Chris Adamson for providing the callosal significance maps.