Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies

Valentina Lorenzetti; Nicholas B Allen; Alex Fornito; Murat Yuecel

Journal article

Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies

Valentina Lorenzetti, Nicholas B Allen, Alex Fornito, Murat Yuecel

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2009

DOI: 10.1016/j.jad.2008.11.021

Abstract

BACKGROUND: While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear. AIMS: To review recent structural magnetic resonance imaging (MRI) research findings in MDD while considering the potential influence of key clinical and demographic variables. METHOD: A selective review of all T1-weighted structural MRI studies published between 2000 and 2007 in adult samples of MDD patients. RESULTS: Volumetric reductions of the hippocampus, basal ganglia and OFC and SGPFC are consistently found in MDD patients, with more persistent forms of MDD (e.g., multiple episodes or repeated ..

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University of Melbourne Researchers

Nick Allen Author Melbourne School of Psychological Sciences

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Grants

Awarded by Australian Research Council

Awarded by NHMRC Program Grant

Awarded by NHMRC CJ Martin Fellowship

Funding Acknowledgements

This research was supported by grants from the Australian Research Council (I.D. DP0557663) Dr Yucel is supported by a NHMRC Program Grant (I.D. 350241) and the Colonial Foundation. Dr Fornito is supported by a J.N. Peters Fellowship and by a NHMRC CJ Martin Fellowship (ID: 454797). Valentina Lorenzetti is supported by a scholarship of the Faculty of Psychology, The University of Bologna; by the international Postgraduate Research Scholarship, and by the Melbourne International Research Scholarship.