Journal article
Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies
Valentina Lorenzetti, Nicholas B Allen, Alex Fornito, Murat Yuecel
JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2009
Abstract
BACKGROUND: While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear. AIMS: To review recent structural magnetic resonance imaging (MRI) research findings in MDD while considering the potential influence of key clinical and demographic variables. METHOD: A selective review of all T1-weighted structural MRI studies published between 2000 and 2007 in adult samples of MDD patients. RESULTS: Volumetric reductions of the hippocampus, basal ganglia and OFC and SGPFC are consistently found in MDD patients, with more persistent forms of MDD (e.g., multiple episodes or repeated ..
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Grants
Awarded by Australian Research Council
Awarded by NHMRC Program Grant
Awarded by NHMRC CJ Martin Fellowship
Funding Acknowledgements
This research was supported by grants from the Australian Research Council (I.D. DP0557663) Dr Yucel is supported by a NHMRC Program Grant (I.D. 350241) and the Colonial Foundation. Dr Fornito is supported by a J.N. Peters Fellowship and by a NHMRC CJ Martin Fellowship (ID: 454797). Valentina Lorenzetti is supported by a scholarship of the Faculty of Psychology, The University of Bologna; by the international Postgraduate Research Scholarship, and by the Melbourne International Research Scholarship.