Journal article

Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis

Mark Walterfang, Amanda G Wood, David C Reutens, Stephen J Wood, Jian Chen, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis



Reductions in the size of the anterior callosum have been described for both first-episode and established schizophrenia and bipolar affective disorder, but never in individuals with psychotic bipolar disorder. We recruited 110 first-episode psychosis subjects (74 schizophrenia spectrum and 36 affective psychosis) and 36 age- and gender-matched controls. The callosum was extracted from a mid-sagittal slice from T1-weighted magnetic resonance images, and total area, length and curvature of the callosum were compared. The schizophrenia-spectrum group showed reductions in thickness of the genu across schizophreniform and schizoaffective disorder and schizophrenia, and the schizoaffective disord..

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Awarded by National Health and Medical Research Council

Awarded by NHMRC

Funding Acknowledgements

This research Was supported by a program grant and project grants from the National Health and Medical Research Council (NHMRC: grant ID numbers: 350241, 970598, 981112), Ian Potter Foundation, Woods Family Trust, and a program grant from the Victorian Health Promotion Foundation. Dr Walterfang was supported by a Stanley Research Centre Grant. Professor McGorry was supported by a NARSAD Distinguished Investigator Award. Dr Stephen Wood is the recipient of a Clinical Career Development Award from the NHMRC (ID: 359223). Dr Amanda Wood was supported by an NHMRC Clinical Postdoctoral Training Fellowship (ID 251755). or Walterfang takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors had full access to all the data in the study.