Journal article

Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory

Christos Pantelis, Stephen J Wood, Tina M Proffitt, Renee Testa, Kate Mahony, Warrick J Brewer, Jo-Anne Buchanan, Dennis Velakoulis, Patrick D McGorry

SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2009

Abstract

Patients with established schizophrenia perform poorly on attentional set-shifting tasks, due to a failure of inhibitory control and/or perseverative errors. However, attentional set-shifting is also dependent on working memory capacity, which is additionally impaired in schizophrenia. No studies in first-episode psychosis have specifically examined the contribution of working memory to set-shifting ability in schizophrenia. We investigated 48 first-episode schizophreniform psychosis/schizophrenia (FE) and 40 chronic schizophrenia (CHR) patients, compared to 67 comparable healthy subjects (CTL). All subjects were assessed using the CANTAB 'attentional set-shifting (IDED)' and 'spatial workin..

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