Journal article
The impact of age at onset of bipolar I disorder on functioning and clinical presentation
F Biffin, S Tahtalian, K Filia, PB Fitzgerald, AR De Castella, S Filia, M Berk, S Dodd, P Callaly, L Berk, K Kelin, M Smith, W Montgomery, J Kulkarni
Acta Neuropsychiatrica | CAMBRIDGE UNIV PRESS | Published : 2009
Abstract
Objectives: Recent studies have proposed the existence of three distinct subgroups of bipolar 1 disorder based on age at onset (AAO). The present study aims to investigate potential clinical and functional differences between these subgroups in an Australian sample. Methods: Participants (n = 239) were enrolled in the Bipolar Comprehensive Outcomes Study (BCOS), a 2-year longitudinal, observational, cross-sectional study. Assessment measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD21), Clinical Global Impressions Scale (CGI-BP), SF-36, SLICE/Life Scale, and the EuroQol (EQ-5D). Participants were also asked about their age at the first major affecti..
View full abstractGrants
Funding Acknowledgements
We thank Eli Lilly for funding this study. We thank Kate Hoy, Peter Enticott, Stuart Lee, and Jerome Maller for their assistance with statistics and proof reading of this report. Katarina Kelin and William Montgomery are employees of Eli illy, who provided funding for this study. Jayashri Kulkarni, Paul Fitzgerald, Anthony de Castella, Michael Berk and Seetal Dodd have received research funding and/or speakers fees and/or funding to attend conferences from Eli Lilly, who provided funding for this study. Meg Smith has received an honorarium to participate in steering committee meetings for the study. Pam Callaly, Lesley Berk, Sacha Filia, Kate Filia, Steve Tahtalian and Frances Biffin have no conflicts of interest.