Journal article

Effects of N-acetylcysteine on substance use in bipolar disorder: A randomised placebo-controlled clinical trial

Michelle Bernardo, Seetal Dodd, Clarissa S Gama, David L Copolov, Olivia Dean, Kristy Kohlmann, Susan Jeavons, Ian Schapkaitz, Murray Anderson-Hunt, Ashley I Bush, Michael Berk

Acta Neuropsychiatrica | CAMBRIDGE UNIV PRESS | Published : 2009

Abstract

OBJECTIVE: To evaluate the effect of N-acetylcysteine (NAC) on substance use in a double-blind, placebo-controlled trial of NAC in bipolar disorder. It is hypothesised that NAC will be superior to placebo for reducing scores on the Clinical Global Impressions scale for Substance Use (CGI-SU). METHODS: Participants were randomised to a 6-months of treatment with 2 g/day NAC (n = 38) or placebo (n = 37). Substance use was assessed at baseline using a Habits instrument. Change in substance use was assessed at regular study visits using the CGI-SU. RESULTS: Among the 75 participants 78.7% drank alcohol (any frequency), 45.3% smoked tobacco and 92% consumed caffeine. Other substances were used by..

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