Journal article

Dietary fatty acid intake affects the risk of developing bone marrow lesions in healthy middle-aged adults without clinical knee osteoarthritis: a prospective cohort study

Yuanyuan Wang, Miranda L Davies-Tuck, Anita Wluka, Andrew Forbes, Dallas R English, Graham G Giles, Richard O'Sullivan, Flavia M Cicuttini



INTRODUCTION: Fatty acids have been implicated in osteoarthritis (OA), yet the mechanism by which fatty acids affect knee structure and consequently the risk of knee OA has not been fully elucidated. Higher intakes of fatty acids have been shown to be associated with the risk of bone marrow lesions (BMLs) in a healthy population. The aim of this study was to examine the association between fatty acid consumption and the incidence of BMLs in healthy middle-aged adults without clinical knee OA. METHODS: Two hundred ninety-seven middle-aged adults without clinical knee OA underwent magnetic resonance imaging (MRI) of their dominant knee at baseline. BMLs were assessed. Of the 251 participants w..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and The Cancer Council Victoria. This study was funded by a program grant from the National Health and Medical Research Council (NHMRC) (209057) and was further supported by infrastructure provided by The Cancer Council Victoria. We would like to acknowledge the NHMRC (project grant 334150), Colonial Foundation, and Shepherd Foundation for support. YW and AEW are the recipients of NHMRC Public Health (Australia) Fellowships (NHMRC 465142 and 317840, respectively). MLD-T is the recipient of Australian Postgraduate Award PhD Scholarship. We would especially like to thank the study participants, who made this study possible.