Journal article
Structural biology of carbohydrate xenoantigens
E Yuriev, M Agostino, W Farrugia, D Christiansen, MS Sandrin, PA Ramsland
Expert Opinion on Biological Therapy | TAYLOR & FRANCIS LTD | Published : 2009
Abstract
Transplantation of organs across species (xenotransplantation) is being considered to overcome the shortage of human donor organs. However, unmodified pig organs undergo an antibody-mediated hyperacute rejection that is brought about by the presence of natural antibodies to Galα(1,3)Gal, which is the major carbohydrate xenoantigen. Genetic modification of pig organs to remove most of the Galα(1,3)Gal epitopes has been achieved, but the human immune system may still recognize residual lipid-linked Galα(1,3) Gal carbohydrates, new (cryptic) carbohydrates or additional non-Galα(1,3) Gal carbohydrate xenoantigens. The structural basis for lectin and antibody recognition of Galα(1,3)Gal carbohydr..
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Funding Acknowledgements
This work was funded by grant ID566722 (to MS Sandrin, D Christiansen and PA Ramstand) from the National Health and Medical Research Council of Australia (NHMRC). M Agostino is a recipient of an Australian Postgraduate Award (APA). PA Ramsland is a recipient of an R Douglas Wright Career Development Award (ID365209) from the NHMRC.