Structural biology of carbohydrate xenoantigens
Elizabeth Yuriev, Mark Agostino, William Farrugia, Dale Christiansen, Mauro S Sandrin, Paul A Ramsland
EXPERT OPINION ON BIOLOGICAL THERAPY | TAYLOR & FRANCIS LTD | Published : 2009
Transplantation of organs across species (xenotransplantation) is being considered to overcome the shortage of human donor organs. However, unmodified pig organs undergo an antibody-mediated hyperacute rejection that is brought about by the presence of natural antibodies to Galalpha(1,3)Gal, which is the major carbohydrate xenoantigen. Genetic modification of pig organs to remove most of the Galalpha(1,3)Gal epitopes has been achieved, but the human immune system may still recognize residual lipid-linked Galalpha(1,3)Gal carbohydrates, new (cryptic) carbohydrates or additional non-Galalpha(1,3)Gal carbohydrate xenoantigens. The structural basis for lectin and antibody recognition of Galalpha..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
This work was funded by grant ID566722 (to MS Sandrin, D Christiansen and PA Ramstand) from the National Health and Medical Research Council of Australia (NHMRC). M Agostino is a recipient of an Australian Postgraduate Award (APA). PA Ramsland is a recipient of an R Douglas Wright Career Development Award (ID365209) from the NHMRC.