Journal article

Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro

Suzana Kovac, Audrey Ferrand, Jean-Pierre Esteve, Anne B Mason, Graham S Baldwin

FEBS JOURNAL | WILEY | Published : 2009

Abstract

Transferrin is the main iron transport protein found in the circulation, and the level of transferrin saturation in the blood is an important indicator of iron status. The peptides amidated gastrin(17) (Gamide) and glycine-extended gastrin(17) (Ggly) are well known for their roles in controlling acid secretion and as growth factors in the gastrointestinal tract. Several lines of evidence, including the facts that transferrin binds gastrin, that gastrins bind ferric ions, and that the level of expression of gastrins positively correlates with transferrin saturation, suggest the possible involvement of the transferrin-gastrin interaction in iron homeostasis. In the present work, the interactio..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health


Awarded by National Health and Medical Research Council of Australia


Awarded by United States Public Health Service


Awarded by Medical Research and Technology in Victoria which is managed by ANZ Trustees


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

This work was supported by grant 5 RO1 GM065926 from the National Institutes of Health (to G. Baldwin), grants 400062 (to G. Baldwin) and 566555 (to G. Baldwin) from the National Health and Medical Research Council of Australia, grant R01 (DK 21739) from the United States Public Health Service (to A. B. Mason), and grant CT8917 from Medical Research and Technology in Victoria which is managed by ANZ Trustees (to A. Ferrand).