Journal article

Screening and Study Enrolment in the Randomized Evaluation of Normal vs. Augmented Level (RENAL) Replacement Therapy Trial

Rinaldo Bellomo



BACKGROUND AND OBJECTIVES: Aspects of trial design, screening and study efficiency can affect recruitment and the findings of the trial itself. A clear understanding of the screening and study inclusion process will assist clinicians in interpreting trial results. DESIGN: Prospective observational data collection on all patients screened for possible inclusion in a randomized controlled trial of normal vs. augmented renal replacement therapy in critically ill patients (the RENAL Trial). SETTING: 35 hospitals in Australia and New Zealand. PARTICIPANTS: All patients screened for the RENAL Trial. RESULTS: We screened 4,551 patients. Of these patients, 767 were ineligible because of lack of incl..

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