Journal article

Altered M-1 Muscarinic Acetylcholine Receptor (CHRM1)-G alpha(q/11) Coupling in a Schizophrenia Endophenotype

Hasib Salah-Uddin, Elizabeth Scarr, Geoffrey Pavey, Kriss Harris, Jim J Hagan, Brian Dean, RA John Challiss, Jeannette M Watson

NEUROPSYCHOPHARMACOLOGY | NATURE PUBLISHING GROUP | Published : 2009

Abstract

Alterations in muscarinic acetylcholine receptor (CHRM) populations have been implicated in the pathology of schizophrenia. Here we have assessed whether the receptor function of the M(1) subtype (CHRM1) is altered in a sub-population of patients with schizophrenia, defined by marked (60-80%) reductions in cortical [3H]-pirenzepine (PZP) binding, and termed 'muscarinic receptor-deficit schizophrenia' (MRDS). Using a [35S]-GTPgammaS-Galpha(q/11) immunocapture method we have assessed whether CHRM1 signalling in human cortex (Brodmann area 9 (BA9)) is altered in post mortem tissue from a MRDS group compared with a subgroup of patients with schizophrenia displaying normal PZP binding, and contro..

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