Journal article

Behavioural and cognitive phenotypes in idiopathic autism versus autism associated with fragile X syndrome

Cheryl Dissanayake, Quang Bui, Danuta Bulhak-Paterson, Richard Huggins, Danuta Z Loesch

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY | WILEY-BLACKWELL PUBLISHING, INC | Published : 2009

Abstract

BACKGROUND: In order to better understand the underlying biological mechanism/s involved in autism, it is important to investigate the cognitive and behavioural phenotypes associated with idiopathic autism (autism without a known cause) and comorbid autism (autism associated with known genetic/biological disorders such as fragile X syndrome). Parental effects associated with each type of autism also serve to cast light on the biological underpinnings of autism. METHOD: Forty-nine participants with idiopathic autism (AD; Mean age: 11.16; SD: 6.08) and their parents (45 mothers; 34 fathers), and 48 participants with fragile X syndrome and co-morbid autism (FXS/AD; Mean age: 17.30; SD: 10.22) a..

View full abstract

Grants

Awarded by NIH


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Funding Acknowledgements

We acknowledge receipt of the NIH Grant No. HD 36071 and Grant No 5MO1RR00069, General Clinical Research Centres Program, National Centre for Research Resources, NIH. We thank Dr Annette Taylor from Kimball Genetics Pty Denver Colorado, USA, and Dr Howard Slater from the Cytogenetics Laboratory, Murdoch Institute, Royal Children's Hospital, Melbourne, Australia, for conducting the molecular FXS tests. We would also like to thank all families who gave their time to participate in this study.