Snail expression is an independent predictor of tumor recurrence in superficial bladder cancers
Franck Bruyere, Benjamin Namdarian, Niall M Corcoran, John Pedersen, Jeremy Ockrim, Bryan B Voelzke, Uttam Mete, Anthony J Costello, Christopher M Hovens
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS | ELSEVIER SCIENCE INC | Published : 2010
BACKGROUND: Epithelial-mesenchymal transition (EMT) is known to play an important role in the development of tumor invasion and progression in tumors of epithelial origin. OBJECTIVES: Our aim was to investigate the role of Snail transcription repressor family members in human bladder pathogenesis. MATERIAL AND METHODS: We evaluated levels of Snail and Slug in 87 patients who received transurethral resection of a transitional cell carcinoma at our institution during the period from June 1999 until November 2003. Immunohistochemistry was performed on tissue microarrays, and expression correlated with pathological variables and clinical outcomes. Degree and intensity of Snail and Slug staining ..View full abstract
This work was supported by funds from the Melbourne Urology Trust, by a generous gift from Roger Riordan from the Cybec Trust. N.M.C. was supported by a Benjamin Rank Surgical Fellowship from the Royal Melbourne Hospital, and a NHMRC Medical Postgraduate Scholarship. B.N. was supported by the 2007 Raelene Boyle Scholarship from the Royal Australasian College of Surgeons.