Journal article

A Pilot, Randomized, Double-Blind, Cross-Over Study of High Cut-Off versus High-Flux Dialysis Membranes

Darren Lee, Michael Haase, Anja Haase-Fielitz, Kathy Paizis, Hermann Goehl, Rinaldo Bellomo



BACKGROUND: High cut-off (HCO) membranes may increase beta(2)-microglobulin (beta2M) removal compared to standard high-flux membranes. METHODS: Eight stable haemodialysis patients were enrolled in a prospective, randomized, double-blind, cross-over study and treated with HCO and high-flux membranes for 2 weeks each, between a 1-week washout period. Primary end point was serum beta2M removal. Secondary end points included serum albumin concentrations, albumin and small solute clearances. RESULTS: HCO membranes achieved significantly lower median post-dialysis beta2M concentration (10.8 vs. 14.2 mg/l; p = 0.003) and greater beta2M reduction ratio (62.3 vs. 51.0%; p < 0.002). Serum albumin decr..

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University of Melbourne Researchers


Funding Acknowledgements

The authors thank the dialysis patients and staff in North East Kidney Services and Dialysis Training Unit for their participation and cooperation with this study, and Gambro, Pty, Ltd., for the supply of the dialysis membranes.Dr. Haase holds a postdoctoral Feodor-Lynen Research Fellowship from the Alexander von Humboldt Foundation, Germany.